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[140]. To date, all other types of DGI and DD have been associated with mutations in DSPP. It should be noted, that with the exception of the abnormal collagen in DGI type I, all of the other forms are associated with abnormalities in an IDP. Due to the collagen anomaly we suggest that the IDPs similarly contribute to the phenotype in DGI type I as the IDPs bind to specific sites on the collagen m
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He recent advances in the field of vaccine technology may provideHe recent advances in the field of vaccine technology may provide valuable insights for the rational design of next-generation vaccine delivery systems. Historically, vaccinology has relied on the use of live attenuated, killed/inactivated, toxoid and subunit vaccines with most of them currently available on the market. Many li
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Families and within the same family, with the identical mutations [154], may be attributable to unknown effects on other genes or toAuthor Manuscript Author Manuscript Author Manuscript Author ManuscriptMatrix Biol. Author manuscript; available in PMC 2017 May 01.Boskey and Villarreal-RamirezPagesimilarly unknown interactions with collagen during development. As noted above, interactions of many o
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Disorders, cancers (VLPs targeting self-antigens) . Particulate delivery systems similar in sizeDisorders, cancers (VLPs targeting self-antigens) . Particulate delivery systems similar in size and geometry to pathogens, such as VLPs, are efficiently uptaken by professional antigen-presenting cells for both MHC classWJV|www.wjgnet.comAugust 12, 2015|Volume 4|Issue 3|Trovato M et al . Vaccine
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Ce in which the N-terminus of the CTD (residues 145?51 in the full-length protein) fit into a helical groove on the symmetric subunit, as confirmed by the observation of several intersubunit NOEs (PDB ID 2KOD). Here, we have used the chemical shift assignments from solid-state NMR experiments reported in reference 29 and backbone N and CR R RDCs measured in solution28 as the only source of experi
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S low-cost, nonreplicating, non-integrating, non-pathogenic E2 vaccines could be designed andS low-cost, nonreplicating, non-integrating, non-pathogenic E2 vaccines could be designed and combined with other approaches to advance the field of vaccinology.CONCLUSIONVaccines play a pivotal role in host protection against infectious diseases and have significantly reduced mortality worldwide. Ho
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Squamous epithelial cell envelope, represents the primary ligand for ClfB and that the interaction between ClfB and loricrin is required for efficient nasal colonisation by S. aureus. Using purified proteins we have demonstrated that ClfB binds loricrin and propose a mechanism by which this binding occurs. We have established a murine model of S. aureus nasal colonisation and have demonstrated red
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Set of 67 manually assigned backbone NOEs, and RDCs, we obtain a dimer structure that is within 2.6 ?backbone rmsd from the homologous structure (Supporting Information Figure 2). Furthermore, the structures are very similar in fold to the structures obtained using conventional structure calculations and a full set of NOEs. Good agreement with the RDCs is indicated by a Q-factor of 0.32 (see Mater