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EP2, EP4 also has a extended C-terminus, which has been implicated in agonist-induced desensitization and internalization (Nishigaki et al., 1996; Bastepe and Ashby, 1999; Desai et al., 2000). Despite the low levels of intracellular cAMP, when activated pursuing personal injury, the EP4 receptor has proven to have neuroprotective qualities. It can be effectively documented that EP4 receptor activa